| Date / Time | Teams | |
 |  19/09/2025 10:00 | Uruguay Montevideo - Minas |
| 19/09/2025 10:00 | San José de Mayo - Aiguá |
| 19/09/2025 10:00 | Canelones B - Juan Lacaze |
| 19/09/2025 10:00 | Cerro Largo - CA Boston River |
| 19/09/2025 10:00 | Racing Montevideo - Toledo |
| 19/09/2025 10:00 | Inter Valandovo - Olympiacos F.C. A |
| 19/09/2025 10:00 | Treinta y Tres - Paysandú |
| 19/09/2025 10:00 | Colonia del Sacramento - Guichón |
